Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens chromosome 12 open reading frame 65 (C12orf65), transcript variant 1 (NM_152269). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q9H3J6 |
| Entry Name | MTRFR_HUMAN |
| Gene Names | MTRFR C12orf65 My030 |
| Alternative Gene Names | |
| Alternative Protein Names | Mitochondrial translation release factor in rescue |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 166 |
| Molecular Weight(Da) | 18828 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MSTVGLFHFPTPLTRICPAPWGLRLWEKLTLLSPGIAVTPVQMAGKKDYPALLSLDENELEEQFVKGHGPGGQATNKTSNCVVLKHIPSGIVVKCHQTRSVDQNRKLARKILQEKVDVFYNGENSPVHKEKREAAKKKQERKKRAKETLEKKKLLKELWESSKKVH |
Background
| Function | FUNCTION: Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:33243891). As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891). {ECO:0000269|PubMed:33243891}. |
| Pathway | |
| Protein Families | Prokaryotic/mitochondrial release factor family |
| Tissue Specificity | Expressed in all areas of the brain tested. {ECO:0000269|PubMed:24198383}. |
QC Data
| Please contact us for specific QC data. |